Human beta -I Tubulin Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB8527R Datasheet / COA / SDS

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FAB8527R-100UG

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Human beta -I Tubulin Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human beta -I Tubulin in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 923425

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Î²-I Tubulin
Met1-His451
Accession # Q9H4B7

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: beta-I Tubulin

beta -tubulin is a 50 kDa cytoskeletal protein which is the a major component of neuronal processes: axons, dendrites, and dendritic spines. beta -tubulin is represented by different isoforms including beta -I, beta -II, beta -III, and beta -IV. Elimination of beta -I isoform will decrease the viability of neuroblastoma cells. Formation of actin tubules may be directly inhibited by beta -I isoform which results in decreasing cellular adhesion. beta -I Tubulin levels in different brain regions of schizophrenia patients undergo noticeable changes suggesting that this isoform may have a specific role in the pathophysiology of this illness by affecting actin tubule formation which is required for cell division and differentiation.

Long Name

Tubulin, Beta 1 Class VI

Entrez Gene IDs

81027 (Human); 545486 (Mouse); 679312 (Rat)

Alternate Names

beta tubulin 1, class VI; betaI Tubulin; beta-I Tubulin; dJ543J19.4; TUBB1; tubulin beta-1 chain; tubulin, beta 1