Human BIM Long (BIM L) Alexa Fluor® 405-conjugated Antibody

Catalog #: AF1325V Datasheet / COA / SDS

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AF1325V-100UG

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Human BIM Long (BIM L) Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human BIM_L in direct ELISAs and Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human BIM_L Long (BIM L)
Ala2-Arg120
Accession # NP_006529

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: BIM Long (BIM L)

BIM_L (also known as Bod) is one of several splice variants of BIM, a pro-apoptotic protein belonging to the BH3 domain-only subgroup of Bcl-2 family members. BIM_L is thought to promote apoptosis by binding and inhibiting the activity of anti-apoptoticBcl-2 family members, thereby inducing the release of cytochrome c from mitochondria. BIM_L is normally sequestered in an inactive conformation from anti-apoptotic Bcl-2 family members through binding to the microtubule-associated dynein motor complex.Certain apoptotic stimuli release BIM_L from microtubules to neutralize anti-apoptotic Bcl-2 family members, allowing for the initiation of apoptosis.

Long Name

Bcl-2 Interacting Mediator of Cell Death

Entrez Gene IDs

10018 (Human); 12125 (Mouse)

Alternate Names

BAM; BCL2L11; BIM Long; BIM; BOD