Human BMX Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: BMX

BMX (Bone marrow tyrosine kinase gene in chromosome X protein; also ETK and NTK38) is a 76‑85 kDa member of the TEC subfamily, Tyr protein kinase family of enzymes. It is a cytoplasmic endothelial and epithelial cell kinase that induces STAT phosphorylation in a Jak-independent manner, and regulates cytokine production via mRNA stabilization. Human BMX is 675 amino acids (aa) in length. It contains one PH domain whose ligation induces activation (aa 6‑109), a zinc-finger region (aa 113‑149), two autophosphorylation sites at Tyr216 and Tyr224, an SH3 and SH2 domain (aa 213‑392) and a kinase catalytic site (aa 417‑675). BMX undergoes proteolysis by caspase 3 to generate a 35 kDa N-terminal (aa 1‑242) fragment, and a 50 kDa C-terminal (aa 243‑675) fragment with enhanced kinase activity.

Product Datasheets

Related Research Areas

• Intracellular Kinases in the Akt Pathway