Human CD-M6PR Lumenal Domain Antibody [Biotin]

R&D Systems | Catalog # BAF5320

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Goat IgG
View all CD-M6PR Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CD-M6PR Lumenal Domain

Specificity

Detects human CD-M6PR Lumenal Domain in Western blots. In Western blots, approximately 40% cross‑reactivity with recombinant mouse CD-M6PR is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human CD-M6PR Lumenal Domain Antibody [Biotin]

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human CD-M6PR Lumenal Domain

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: CD-M6PR

The CD-M6PR (cation-dependent mannose 6-phosphate receptor; also CD-MPR) is a 44‑46 kDa member of the P-type lectin family of proteins. It is ubiquitously expressed, found internally, and transports newly formed mannose 6-phosphate bearing acid hydrolases from the secretory pathway to acidified lysosomes. Mature human CD-M6PR is a type I transmembrane glycoprotein that is 251 amino acids (aa) in length. It functions as a homodimer, and contains a 159 aa luminal region (aa 27‑185) plus a 67 aa cytoplasmic domain. The aa residues Gln66, Arg111, Glu133 and Tyr143 recognize carbohydrate; Asp103 interacts with divalent cation (Mn2+), increasing ligand affinity and receptor oligomerization. Over aa 27‑184, human CD-M6PR shares 90% aa identity with mouse CD-M6PR.

Long Name

Cation Dependent Mannose-6-Phosphate Receptor 46 kDa

Alternate Names

CD-MPR, CDM6PR, M6PR, MPR46, MPRD, SMPR

Entrez Gene IDs

4074 (Human); 17113 (Mouse); 312689 (Rat)

Gene Symbol

M6PR

Additional CD-M6PR Products

Product Documents for Human CD-M6PR Lumenal Domain Antibody [Biotin]

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human CD-M6PR Lumenal Domain Antibody [Biotin]

For research use only

Related Research Areas

Lysosomal Enzymes

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