CD96 (also known as Tactile) is a 160 kDa type I transmembrane glycoprotein that contains three Ig-like domains in its extracellular region. It is expressed on CD4+ and CD8+ T cells, NK cells, and select B cells. CD96 binds to CD155/PVR and participates in NK cell-mediated lysis of CD155+ target cells. Alternate splicing generates a short variant (CD96v2) which lacks 16 amino acids (aa) within the second Ig-like domain. CD96v2 is the predominant isoform in many cell types and exhibits even greater binding affinity with CD155 than does full length CD96. A soluble form of CD96 circulates in the serum. Over aa 22-501, human CD96v2 shares 55% aa sequence identity with mouse and rat CD96.
Human CD96 v2 APC‑conjugated Antibody
R&D Systems | Catalog # FAB6199A
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Val22-Asp501
Accession # NP_005807
Specificity
Clonality
Host
Isotype
Scientific Data Images for Human CD96 v2 APC‑conjugated Antibody
Detection of CD96v2 in Human PBMC Lymphocytes by Flow Cytometry.
Human peripheral blood mononuclear cell (PBMC) lymphocytes were stained with Mouse Anti-Human CD3e Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB100F) and either (A) Mouse Anti-Human CD96v2 APC-conjugated Monoclonal Antibody (Catalog # FAB6199A) or (B) Mouse IgG1Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.
Applications for Human CD96 v2 APC‑conjugated Antibody
Flow Cytometry
Sample: Human peripheral blood mononuclear cell (PBMC) lymphocytes
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Advanced Features
- Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
- Spillover Popups - Visualize the spectra of individual fluorochromes
- Antigen Density Selector - Match fluorochrome brightness with antigen density
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: CD96
Alternate Names
Gene Symbol
UniProt
Additional CD96 Products
Product Documents for Human CD96 v2 APC‑conjugated Antibody
Product Specific Notices for Human CD96 v2 APC‑conjugated Antibody
For research use only
Citations for Human CD96 v2 APC‑conjugated Antibody
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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- Troubleshooting Guide: Fluorokine Flow Cytometry Kits
- View all Protocols, Troubleshooting, Illustrated assays and Webinars