Human Claudin-19 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB6970U Datasheet / COA / SDS

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FAB6970U-100UG

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All Claudin-19 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Claudin-19 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Claudin-19 in direct ELISAs.

Source

Monoclonal Mouse IgG1 Clone # 693202

Purification

Protein A or G purified

Immunogen

NS0 mouse myeloma cell line transfected with human Claudin-19
Accession # Q8N6F1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Claudin-19

Claudin-19 is a 23 kDa multipass membrane protein in the Claudin family of epithelial tight junction proteins. Claudin-19 is expressed by renal tubular epithelial cells, retinal pigment epithelial cells, and Schwann cells. It interacts with Claudin-16 to form cation-selective paracellular channels in the thick ascending loop of the kidney. Mutations of Claudin-19 are associated with renal disorders of magnesium and calcium reabsorption. Human Claudin-19 shares 95% aa sequence identity with mouse and rat Claudin-19. An alternate splice form of human Claudin-19 has a deletion within the C-terminal cytoplasmic region.

Entrez Gene IDs

149461 (Human); 242653 (Mouse); 298487 (Rat)

Alternate Names

claudin 19; Claudin19; Claudin-19; CLDN19