Human Gastrokine 1 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB6395R Datasheet / COA / SDS

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FAB6395R-100UG

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Human Gastrokine 1 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Gastrokine 1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse Gastrokine 1 is observed.

Source

Monoclonal Mouse IgG1 Clone # 665701

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Gastrokine 1
Asn35-Asn199
Accession # Q9NS71

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Gastrokine 1

Gastrokine 1 (GKN1; also CA11 and AMP-18) is an 18 kDa member of the CA11 protein family. It has limited expression, being restricted to mucous secreting pyloric atrial epithelium. Gastrokine 1 appears to promote epithelial proliferation and migration, and induce the formation of tight junctions between epithelial cells. Mature human Gastrokine 1 is 165 amino acids (aa) in length. Based on the SwissProt sequence, it possesses one BRICHOS domain (aa 54-150) that contains a mitogenic sequence (aa 97-117). There is one potential alternative start site 14 aa upstream of the standard site that does not appear to be utilized. Over aa 21-185 (aa 35-199 of SwissProt), human Gastrokine 1 shares 65% aa identity with mouse Gastrokine 1.

Long Name

Take out Column D name

Entrez Gene IDs

56287 (Human); 66283 (Mouse); 297418 (Rat)

Alternate Names

18 kDa antrum mucosa protein; AMP18; AMP-18; AMP18BRICHOS domain containing 1; BRICD1; CA11; CA11MGC70354; FOV; Foveolin; Gastrokine 1; gastrokine-1; GKN1; Protein CA11