Human GluR4 Alexa Fluor™ Plus 488‑conjugated Antibody

R&D Systems | Catalog # FAB113633AFP488

R&D Systems
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2913C
View all GluR4 Primary Antibodies »

Product Specifications

Specificity

Detects human GluR4 in direct ELISA.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for Human GluR4 Alexa Fluor™ Plus 488‑conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: GluR4

Ionotropic glutamate receptor 4 (GluR4) is a 100.9 kDa protein that is part of a family (iGluR 1-7) of ligand-gated ion channels that mediates fast transmission of neurotransmitter signals in neuronal cells. These receptors respond to several agonists including N-methyl-d-aspartic acid (NMDA), alpha -amino-3-hydroxyl-5-methylisoxazole-4-proprionic acid (AMPA), or kainic acid (KA). iGluRs are tetrameric structures made by the dimerization of dimers. These receptors can form through a combination of iGluR1-iGluR4 subunits. Mature human GluR4 is a 902 amino acid (aa) molecule, and alternate gene-splicing results in transcript variations encoding different isoforms that may effect their signal transduction properties. GluR4 is made up of an extracellular amino-terminal domain (ATD), ligand binding domain (LBD), a common pore-forming transmembrane domain (TMD) and an intracellular C-terminal domain (CTD).  GluR4's clam-shell shaped LBD binds to agonists. The LBD closes upon ligand binding to induce a conformational change to the TMD, resulting in the ion channel opening. GluR4 is highly expressed in areas that utilize fast kinetics and rapid desensitization. Examples of GluR4 expression include tissues of the central cervical nucleus in rats, the outer plexiform layer of goldfish, the retinal cells of chicken embryos and the human cerebral cortex.

Long Name

Glutamate Receptor 4

Alternate Names

GluA4, GLURD

Entrez Gene IDs

2893 (Human); 14802 (Mouse); 29629 (Rat)

Gene Symbol

GRIA4

UniProt

P48058.2

Additional GluR4 Products

Product Documents for Human GluR4 Alexa Fluor™ Plus 488‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human GluR4 Alexa Fluor™ Plus 488‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Protocols

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FAQs

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