Human GPR88 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB10828U Datasheet / COA / SDS

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FAB10828U-100UG

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Human GPR88 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human GPR88 in direct ELISAs.

Source

Monoclonal Mouse IgG1 Clone # 1039830

Purification

Protein A or G purified

Immunogen

Human GPR88 synthetic peptide

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: GPR88

GPR88 is an orphan receptor that probably belongs to the G-protein coupled receptor family. Ligands for this receptor still largely remain unknown but agonists have been discovered. It is a brain-specific receptor with almost exclusive expression in the striatum, being preferentially localized in medium spiny neurons. Because of its expression, GPR88 is emerging as a drug target for CNS disorders such as schizophrenia, Parkinson's disease, anxiety, and addiction. Gpr88 KO mice data suggests that striatal GPR88 receptors influence activity in a range of procedures integrated by prefrontal, orbitofrontal and anterior cingulate cortico-striatal-thalamic loops leading to altered cognitive, motivational and reward evaluation processes.

Long Name

G Protein-coupled Receptor 88

Entrez Gene IDs

54112 (Human); 64378 (Mouse); 64443 (Rat)

Alternate Names

G protein coupled receptor 88; G protein-coupled receptor 88; GPR88; G-protein coupled receptor 88; probable G-protein coupled receptor 88; STRG; Striatum-specific G-protein coupled receptor