Human LRRTM3 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB4898V Datasheet / COA / SDS

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FAB4898V-100UG

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Human LRRTM3 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human LRRTM3 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant mouse (rm) LRRTM3 and no cross-reactivity with recombinant human LRRTM1, 2, or 4 is observed.

Source

Monoclonal Mouse IgG2b Clone # 568318

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human LRRTM3
Glu31-Lys419
Accession # Q86VH5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LRRTM3

Human LRRTM3 (leucine-rich repeat transmembrane neuronal 3) is a 63 kDa (predicted) type I transmembrane glycoprotein that is one of four LRRTM family members within the LRR protein superfamily (1). The LRRTM3 cDNA encodes 581 amino acids (aa), including a 389 aa extracellular region that shares 98% aa identity with mouse and rat LRRTM3. Isoform 2 lacks cytoplasmic aa 514-581. LRRTMs in mouse show distinct expression patterns during formation of the central nervous system (CNS) and expression persists in adult brain. LRRTM3 promotes processing of amyloid precursor protein by BACE1, and may be mutated in late-onset Alzheimer’s disease.

Long Name

Leucine Rich Repeat Transmembrane Neuronal 3

Entrez Gene IDs

347731 (Human); 216028 (Mouse); 294380 (Rat)

Alternate Names

leucine rich repeat transmembrane neuronal 3; leucine-rich repeat transmembrane neuronal protein 3; LRRTM3; MGC131810