Human LYPD1 Alexa Fluor® 488-conjugated Antibody

Catalog #: AF6855G Datasheet / COA / SDS

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AF6855G-100UG

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Human LYPD1 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human LYPD1 in direct ELISAs. In direct ELISAs, less than 1% cross-reactivity with recombinant human LYPD3 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human LYPD1
Cys54-Ser116
Accession # Q8N2G4

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LYPD1

LYPD1 (Ly6/PLAUR-domain containing protein 1; also Lynx2 and PHTS) is a 15-20 kDa member of the Ly6 family of GPI-anchored proteins. It is expressed on postmitotic neurons in multiple locations, performing multiple functions. Two suggested functions include the ability to 1) block cell proliferation, and 2) bind to acetylcholine receptors, promoting their desensitization. Human LYPD1 preproprecursor is 141 amino acids (aa) in length. It contains a signal sequence (aa 1-20), a 97 aa mature region (aa 21-117), and a cleavable prodomain that, when cleaved, generates a GPI-linked form (aa 118-141). The mature molecule contains one Ly6 domain (aa 25-107). There are multiple potential isoform variants. One possesses an alternative start site at Met53, a second contains a 21 aa substitution for aa 1-5, a third shows a 21 aa substitution for aa 64-141, and a fourth possesses a 29 aa substitution for aa 65-141. Over aa 54-116, human and mouse LYPD1 are identical in aa sequence.

Long Name

Ly6/PLAUR Domain-containing Protein 1

Entrez Gene IDs

116372 (Human); 72585 (Mouse); 360838 (Rat)

Alternate Names

FLJ41033; LY6/PLAUR domain containing 1; ly6/PLAUR domain-containing protein 1; LYPD1; LYPDC1; MGC29643; PHTS; Putative HeLa tumor suppressor