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Human/Mouse/Bovine Integrin  alpha 6/CD49f APC-conjugated Antibody

Catalog #: FAB13501A
16 Citations Datasheet / COA / SDS
Clone GoH3 was used by HLDA to establish CD designation
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FAB13501A

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Detection of Integrin alpha 6/CD49f in Human Blood Lymphocytes by Flow Cytometry.
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Citations (16)
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Human/Mouse/Bovine Integrin  alpha 6/CD49f APC-conjugated Antibody Summary

Species Reactivity
Human, Mouse, Bovine
Specificity
Detects human, mouse, and bovine Integrin alpha 6/CD49f. Recognizes an epitope in the extracellular domain of the Integrin alpha 6 subunit.
Source
Monoclonal Rat IgG2A Clone # GoH3
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse mammary tumor cells
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Integrin a6/CD49f antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of Integrin alpha 6/CD49f in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Rat Anti-Human/Mouse/Bovine Integrin a6/CD49f APC-conjugated Monoclonal Antibody (Catalog # FAB13501A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry Detection of Integrin a6/CD49f antibody in Mouse Splenocytes antibody by Flow Cytometry. View Larger

Detection of Integrin alpha 6/CD49f in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Human/Mouse/Bovine Integrin a6/CD49f APC-conjugated Monoclonal Antibody (Catalog # FAB13501A) and Rat Anti-Mouse CD3 PE-conjugated Monoclonal Antibody (Catalog # FAB4841P). Quadrant markers were set based on control antibody staining (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Integrin alpha 6/CD49f

Integrin alpha 6 (also VLA-6, CD49F and ITA6) is a 130-150 kDa member of the Integrin alpha chain family of molecules. Mature Integrin  alpha 6 is a 1107 amino acid (aa) type I transmembrane glycoprotein that contains a 1027 aa extracellular region and a 93 aa cytoplasmic tail. The ECD is cleaved to generate a disulfide-linked dimer that shows a 125 kDa heavy chain (aa 24-938), and a 30-31 kDa membrane-bound light chain (aa 942-1130). Integrin alpha 6 forms a nondisulfide-linked heterodimeric complex with both integrin beta 1 and beta 4. Each complex serves as a receptor for laminin.

Entrez Gene IDs
3655 (Human); 16403 (Mouse); 101925271 (Cynomolgus Monkey)
Alternate Names
CD49 antigen-like family member F; CD49f antigen; CD49f; DKFZp686J01244; FLJ18737; Integrin alpha 6; integrin alpha-6; integrin alpha6B; integrin, alpha 6; ITGA6; ITGA6B; Platelet gpl; VLA-6

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Citations for Human/Mouse/Bovine Integrin  alpha 6/CD49f APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

16 Citations: Showing 1 - 10
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  1. Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descent
    Authors: Kumar, B;Khatpe, AS;Guanglong, J;Batic, K;Bhat-Nakshatri, P;Granatir, MM;Addison, RJ;Szymanski, M;Baldridge, LA;Temm, CJ;Sandusky, G;Althouse, SK;Cote, ML;Miller, KD;Storniolo, AM;Nakshatri, H;
    Nature communications
  2. Dual TGF beta /BMP pathway inhibition enables expansion and characterization of multiple epithelial cell types of the normal and cancerous breast.
    Authors: Mayuri Prasad, Brijesh Kumar, Poornima Bhat-Nakshatri, Manjushree Anjanappa, George Sandusky, Kathy D. Miller et al.
    Molecular Cancer Research
  3. Chromosomal instability in human trophoblast stem cells and placentas
    Authors: Wang, D;Cearlock, A;Lane, K;Xu, C;Jan, I;McCartney, S;Glass, I;McCoy, R;Yang, M;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Affinity Purification
  4. Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
    Authors: Kim, H;Aliar, K;Tharmapalan, P;McCloskey, CW;Kuttanamkuzhi, A;Grünwald, BT;Palomero, L;Mahendralingam, MJ;Waas, M;Mer, AS;Elliott, MJ;Zhang, B;Al-Zahrani, KN;Langille, ER;Parsons, M;Narala, S;Hofer, S;Waterhouse, PD;Hakem, R;Haibe-Kains, B;Kislinger, T;Schramek, D;Cescon, DW;Pujana, MA;Berman, HK;Khokha, R;
    Cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity
    Authors: B Kumar, AK Adebayo, M Prasad, ML Capitano, R Wang, P Bhat-Naksh, M Anjanappa, E Simpson, D Chen, Y Liu, JM Schilder, AB Colter, C Maguire, CJ Temm, G Sandusky, EH Doud, AB Wijeratne, AL Mosley, HE Broxmeyer, H Nakshatri
    Science Advances, 2022-01-12;8(2):eabh3375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Successful transplantation of spermatogonial stem cells into the seminiferous tubules of busulfan-treated mice
    Authors: H Azizi, A Niazi Taba, T Skutella
    Reproductive health, 2021-09-23;18(1):189.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. BET bromodomain inhibitors regulate keratinocyte plasticity
    Authors: G Schutzius, C Kolter, S Bergling, F Tortelli, F Fuchs, S Renner, V Guagnano, S Cotesta, H Rueeger, M Faller, L Bouchez, A Salathe, F Nigsch, SM Richards, M Louis, V Gruber, A Aebi, J Turner, F Grandjean, J Li, C Dimitri, JR Thomas, M Schirle, J Blank, P Drueckes, A Vaupel, R Tiedt, PW Manley, J Klopp, R Hemmig, F Zink, N Leroy, W Carbone, G Roma, CG Keller, N Dales, A Beyerbach, A Zimmerlin, D Bonenfant, R Terranova, A Berwick, S Sahambi, A Reynolds, LL Jennings, H Ruffner, P Tarsa, T Bouwmeeste, V Driver, M Frederikse, F Lohmann, S Kirkland
    Nature Chemical Biology, 2021-01-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells
    Authors: HC Chiang, X Zhang, J Li, X Zhao, J Chen, HT Wang, I Jatoi, A Brenner, Y Hu, R Li
    Nucleic Acids Res., 2019-06-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. PDGFR?+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
    Authors: PA Joshi, PD Waterhouse, K Kasaian, H Fang, O Gulyaeva, HS Sul, PC Boutros, R Khokha
    Nat Commun, 2019-04-15;10(1):1760.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Normal breast-derived epithelial cells with luminal and intrinsic subtype-enriched gene expression document inter-individual differences in their differentiation cascade
    Authors: B Kumar, MS Prasad, P Bhat-Naksh, M Anjanappa, M Kalra, N Marino, AMV Storniolo, X Rao, S Liu, J Wan, Y Liu, H Nakshatri
    Cancer Res., 2018-07-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
    Authors: X Zhang, HC Chiang, Y Wang, C Zhang, S Smith, X Zhao, SJ Nair, J Michalek, I Jatoi, M Lautner, B Oliver, H Wang, A Petit, T Soler, J Brunet, F Mateo, M Angel Puja, E Poggi, K Chaldekas, C Isaacs, BN Peshkin, O Ochoa, F Chedin, C Theoharis, LZ Sun, TJ Curiel, R Elledge, VX Jin, Y Hu, R Li
    Nat Commun, 2017-06-26;8(0):15908.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population
    Authors: J Gómez-Mira, M Palafox, L Paré, G Yoldi, I Ferrer, S Vila, P Galván, P Pellegrini, H Pérez-Mont, A Igea, P Muñoz, M Esteller, AR Nebreda, A Urruticoec, I Morilla, S Pernas, F Climent, MT Soler-Mons, A Petit, V Serra, A Prat, E González-S
    Stem Cell Reports, 2017-04-27;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Flow Cytometry
  13. A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development
    Authors: M Kitayama, K Mizutani, M Maruoka, K Mandai, S Sakakibara, Y Ueda, T Komori, Y Shimono, Y Takai
    J. Biol. Chem, 2016-01-12;291(11):5817-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4.
    Authors: Chen C, Murray P, Jiang T, Plikus M, Chang Y, Lee O, Widelitz R, Chuong C
    J Invest Dermatol, 2014-03-11;134(8):2086-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells.
    Authors: Martignani E, Eirew P, Accornero P
    PLoS ONE, 2010-10-19;5(10):e13372.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. A system for detecting high impact-low frequency mutations in primary tumors and metastases
    Authors: Manjushree Anjanappa, Yangyang Hao, Edward R Simpson, Poornima Bhat-Nakshatri, Jennifer B Nelson, Sarah A Tersey et al.
    Oncogene

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