Human/Mouse Kir2.1 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB9548U Datasheet / COA / SDS

Recombinant Monoclonal Antibody

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FAB9548U-100UG

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Human/Mouse Kir2.1 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human Kir2.1 in direct ELISAs. Detects human and mouse Kir2.1 in Immunohistochemistry.

Source

Monoclonal Rabbit IgG Clone # 2153C

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Kir2.1
Asn352-Ile427
Accession # P63252

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Kir2.1

Human Inward Rectifier Potassium Channel 2 (KIR2.1), also known as KCNJ2, is a 427 amino acid (aa) integral membrane protein with 98% homology with mouse and rat KIR2.1. This potassium channel preferentially allows potassium to flow into the cell, which is thought to generate action potential waveform and excitability in neuronal and muscle tissues. Mutations in the KIR2.1 gene are associated with Andersen syndrome, with associated paralysis, cardiac arrhythmias and dysmorphic features. KIR2.1 is widely expressed, notably in heart, placenta, lung, skeletal muscle, kidney and spleen. Expression of KIR2.1 is necessary for development of mature cardiomyocytes from mouse embryonic stem cells.

Long Name

Inward Rectifier K(+) Channel Kir2.1

Entrez Gene IDs

3759 (Human); 16518 (Mouse); 29712 (Rat)

Alternate Names

ATFB9; Cardiac inward rectifier potassium channel; HHBIRK1; HHIRK1; HIRK1; Inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; inward rectifier potassium channel 2; IRK1; IRK-1; IRK1LQT7; KCNJ2; Kir2.1; LQT7; Potassium channel, inwardly rectifying subfamily J member 2; potassium inwardly-rectifying channel, subfamily J, member 2; SQT3