Human/Mouse PBR Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB10045N Datasheet / COA / SDS

Recombinant Monoclonal Antibody

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FAB10045N-100UG

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Human/Mouse PBR Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human PBR in direct ELISAs. Detects human and mouse PBR in Western blots.

Source

Monoclonal Rabbit IgG Clone # 2393B

Purification

Protein A or G purified

Immunogen

Synthetic peptide containing human PBR
Accession # P30536

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PBR

PBR promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism. PBR is expressed at the highest levels under normal conditions in tissues that synthesize steroids. Aberrant expression of PBR has been linked to multiple diseases, including cancer, brain injury, neurodegeneration and ischemia-reperfusion injury.

Long Name

Peripheral-type Benzodiazepine Receptor

Entrez Gene IDs

706 (Human)

Alternate Names

benzodiazepine peripheral binding site; BZRPDBI; IBP; MBRPBS; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBRBPBS; PBRS; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBSbenzodiazapine receptor (peripheral); PTBR; translocator protein (18kDa); translocator protein; TSPO