Human/Mouse Plexin C1 Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB3887N Datasheet / COA / SDS

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FAB3887N-100UG

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Human/Mouse Plexin C1 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human Plexin C1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Plexin A4, B1, B2, B3, D1, recombinant mouse Plexin A1, A2, or A3 is observed.

Source

Monoclonal Mouse IgG2b Clone # 544232

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Plexin C1
Ile49-Ser161
Accession # O60486

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Plexin C1

Plexin C1 (also VESPR and CD232) is a 210 kDa member of the plexin-C subfamily, plexin family of proteins. It is a type I transmembrane glycoprotein that is found on monocytes, dendritic cells and neutrophils. Plexin C1 binds Sema7A, and its viral counterpart, vaccinia semaphorin A39R. Ligation induces actin cytoskeletal rearrangement and cell immobilization. Mature human Plexin C1 is 1534 amino acids (aa) in length. It contains a 910 aa extracellular domain (ECD) and a 603 aa cytoplasmic region. The ECD contains one Sema-domain (aa 49-440), two PSI domains (aa 454-605) and two IPT regions (aa 664-842). Over aa 49-161, human Plexin C1 shares 92% aa identity with mouse Plexin C1.

Entrez Gene IDs

10154 (Human); 54712 (Mouse); 362873 (Rat)

Alternate Names

CD232 antigen; CD232; plexin (semaphorin receptor); Plexin C1; PLXNC1; PLXN-C1; receptor for viral semaphorin protein; receptor for virally-encoded semaphorin; VESPR; VESPRplexin-C1; Virus-encoded semaphorin protein receptor