Human/Mouse/Rat alpha -Cardiac Actin Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB93081U Datasheet / COA / SDS

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FAB93081U-100UG

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Human/Mouse/Rat alpha -Cardiac Actin Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human alpha -Cardiac Actin in direct ELISAs. Detects human,mouse, and rat alpha -Cardiac Actin in Western blots.

Source

Monoclonal Mouse IgG2a Clone # 959615

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Î±-Cardiac Actin
Asp3-Phe377
Accession # P68032

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: alpha-Cardiac Actin

Actin, alpha cardiac muscle 1 (ACTC1) is a 377 aa cytoskeletal filament in cardiac muscle which interacts with the 50-KDa domain of the myosin motor domain in cardiac muscle contraction. Actin is highly conserved across species, and differs from skeletal muscle actin (ACTA1) by only four amino acids. Mutations in the ACTC1 gene are linked to familial hypertrophy cardiomyopathy, atrial septal defects, arrhythmia, and chronic inflammatory cardiomyopathy.

Long Name

Actin, Alpha, Cardiac Muscle 1

Entrez Gene IDs

70 (Human); 11464 (Mouse)

Alternate Names

ACTC; ACTC1; actin, alpha, cardiac muscle 1; alpha-Cardiac Actin; ASD5; Cardiac alpha-Actin; CMD1R; CMH11; LVNC4