Human/Mouse/Rat Peroxiredoxin 4 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Peroxiredoxin 4

Peroxiredoxin 4 (Prx-IV; also known as PRDX4 and thioredoxin peroxidase AOE372) is a 30-32 kDa, widely expressed cytoplasmic antioxidant enzyme that belongs to the typical 2-Cys class of the TSA/ahpC family of peroxiredoxins. It exists as either a homodimer, or heterodimer with PRDX1. PRDX4 reportedly counteracts
p53‑mediated generation of ROS, and regulates NF kappa B via I kappa B-alpha. Human PRDX4 is 271 amino acids (aa) in length and contains an N-terminal poly-Leu region
(aa 20‑30) and a 159 thioredoxin domain (aa 79‑237). There is one catalytic cysteine at Cys124. Over amino acids 1‑271, human PRDX4 shares 89% aa identity with mouse and rat PRDX4.

Product Datasheets

Related Research Areas

• Anti-oxidant Molecules
• Oxidative Stress
• Redox Enzymes