Human/Mouse/Rat Substance P Alexa Fluor® 532-conjugated Antibody

Catalog #: FAB4375X Datasheet / COA / SDS

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FAB4375X-100UG

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Human/Mouse/Rat Substance P Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat Substance P.

Source

Monoclonal Mouse IgG1 Clone # 266815

Purification

Protein A or G purified

Immunogen

KLH-coupled mouse Substance P synthetic peptide
RPKPQQFFGLM

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Substance P

Substance P (Neurokinin-1), is member of the tachykinin peptide family. Processing of preprotachykinin isoforms generates Substance P and other tachykinins. Active Substance P is an 11 amino acid peptide, RPKPQQFFGLM, that is identical across all mammalian species. Substance P is mainly secreted from C-type fibers of primary sensory afferent neurons after stimulation through protease-activated receptor 2 (PAR2). Substance P binds primarily to the neurokinin 1 receptor on neurons in the dorsal horn, transmitting pain signals through the central nervous system.

Entrez Gene IDs

6863 (Human)

Alternate Names

neurokinin 1; neurokinin 2; neurokinin A; Neurokinin-1; neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma); neuropeptide gamma; neuropeptide K; NK2; NKA; NKNAneurokinin alpha; NPK; PPT; protachykinin-1; substance K; Substance P; TAC1; TAC2neuromedin L; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2; tachykinin, precursor 1