Human/Mouse Tec Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB6519U Datasheet / COA / SDS

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FAB6519U-100UG

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Human/Mouse Tec Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human Tec in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG2b Clone # 663921

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Tec
Met1-Met187
Accession # P42680

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Tec

The tyrosine protein kinase Tec is an approximately 70 kDa member of the protein kinase superfamily, tyrosine protein family, and Tec subfamily. Human Tec is 631 amino acids (aa) in length. Amino acid residues 4-111 constitute a Tec pleckstrin homology (PH) domain, and aa 113-149 make up a Btk-type zinc finger. Residues 179-239 form a Src homology 3 (SH3) domain, and aa 247-345 make up a Src homology 2 (SH2) domain. The region involving positions 365-620 constitutes the catalytic domain of the protein tyrosine kinases. Human Tec shares 94% aa sequence identity with mouse Tec. Human Tec is expressed in hematopoietic cell lines including B-cell, T-cell, and myeloid lineages.

Long Name

Translocated in Extraskeletal Chondrosarcoma Protein Tyrosine Kinase

Entrez Gene IDs

7006 (Human)

Alternate Names

EC 2.7.10; EC 2.7.10.2; MGC126760; MGC126762; PSCTK4; PSCTK4tyrosine-protein kinase Tec; tec protein tyrosine kinase; Tec