Human Neurophysin II Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB009S Datasheet / COA / SDS

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FAB009S-100UG

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Human Neurophysin II Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Neurophysin II in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 62865

Purification

Protein A or G purified

Immunogen

Synthetic peptide containing human Neurophysin II
Accession # P01186

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Neurophysin II

Arginine vasopressin (AVP)/Neurophysin 2 is a hormone synthesized in neurons in the hypothalamus that specifically binds vasopressin. Vasopressin has a direct antidiuretic action on the kidney and causes vasoconstriction of the peripheral vessels. Vasopressin regulates the tonicity of body fluid by causing the kidneys to reabsorb solute-free water and returning it to the circulation from the tubules of the nephron. AVP released in high concentrations may also raise blood pressure by inducing vasoconstriction. The stimulus for secretion of vasopressin is increased osmolality of the plasma which is monitored by the hypothalamus. Vasopressin is often used to manage anti-diuretic hormone deficiency.

Entrez Gene IDs

551 (Human); 24221 (Rat)

Alternate Names

arginine vasopressin; ARVP; AVP; AVP-NPII; AVRP; neurohypophyseal; Neurophysin II; NP2; vasopressin-neurophysin 2-copeptin; VP