Human Orexin R2/HCRTR2 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Orexin R2/HCRTR2

Orexin R2 (Orexin Receptor 2), also known as HCRTR2 (Hypocretin Receptor 2) or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of Orexin Rs/HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. It also influences reward circuits involving food or addictive drugs. The extracellular portions of human Orexin R2/HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat Orexin R2/HCRTR2, respectively.

Product Datasheets

Related Research Areas

• G Protein-Coupled Receptors in Nutrition and Appetite
• Metabolic Peptide Hormones and Regulators
• Neurotransmitter G Protein-Coupled Receptors
• Nutrition and Appetite
• Obesity
• Orexin and Receptors
• Peptide Hormone G Protein-Coupled Receptors