Human PAUF/ZG16B Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB7777N Datasheet / COA / SDS

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FAB7777N-100UG

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All PAUF/ZG16B Antibodies

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Human PAUF/ZG16B Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human PAUF/ZG16B in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG1 Clone # 817310

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PAUF/ZG16B
Gly53-Arg208
Accession # Q96DA0

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PAUF/ZG16B

PAUF (pancreatic adenocarcinoma upregulated factor), gene name ZG16B (zymogen granule protein 16B), is a 156 amino acid, approximately 20-25 kDa secreted protein that is a member of the jacalin-binding lectin family. PAUF expression is thought to be restricted to primates, but the related ZG16P, which shares approximately 25% amino acid sequence identity, is more widely expressed. Human PAUF is overexpressed in pancreatic adenocarcinoma, binds Toll-like receptors TLR2 and TLR4, and inhibits CXCR4-dependent, TLR2-mediated NF-kB activation. It facilitates tumor growth, adhesiveness, and production of pro-tumorigenic cytokines.

Long Name

Pancreatic Adenocarcinoma Upregulated Factor

Entrez Gene IDs

124220 (Human)

Alternate Names

DKFZp762P2216; EC 3.1.2; EC 3.4.19.12; EECP; HRPE773; hTrabid; JCLN2; LOC124220; PAUF; PRO1567; TRABIDubiquitin thioesterase ZRANB1; TRAF-binding protein domain; ZG16B; Zinc finger Ran-binding domain-containing protein 1; zinc finger, RAN-binding domain containing 1