Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1114804
View all Perilipin-4 Primary Antibodies »

Product Specifications

Immunogen

Synthetic Peptide

Specificity

Detects a synthetic peptide specific for human PLIN-4 around amino acid 1085 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human Perilipin-4 Antibody (1114804) [Alexa Fluor™ Plus 680]

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Perilipin-4

Perilipin-4 (PLIN4) is a member of the perilipin protein family, with a molecular weight of approximately 135 kDa. The perilipin family comprises lipid droplet-associated proteins that play key roles in lipid metabolism, storage, and mobilization within cells. PLIN4 is primarily expressed in adipose tissue and other lipid-storing cells, where it is localized to the surface of lipid droplets, protecting them from untimely lipolysis and promoting efficient lipid storage. It is thought to act in conjunction with other members of the perilipin family to regulate lipid droplet dynamics and lipid release in response to metabolic cues. PLIN4 is implicated in diverse biological processes, including energy homeostasis and thermogenesis, and alterations in its expression have been associated with metabolic disorders such as obesity, diabetes, and fatty liver disease. Additionally, dysregulation of PLIN4 has been linked to lipid accumulation in tissues, emphasizing its critical role in lipid metabolism and energy storage. Recent research suggests a growing potential for PLIN4 as a biomarker for metabolic disease and as a target for therapeutic interventions aimed at modulating lipid storage and metabolic health.

References

  1. Brasaemle DL, Dolios G, Shapiro L, Wang R. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem. 2004 Nov 5;279(45):46835-42. doi: 10.1074/jbc.M409340200. Epub 2004 Aug 27. PMID: 15337753.
  2. Kimmel AR, Sztalryd C. The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis. Annu Rev Nutr. 2016 Jul 17;36:471-509. doi: 10.1146/annurev-nutr-071813-105410. PMID: 27431369.
  3. Sztalryd C, Brasaemle DL. The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1221-1232. doi: 10.1016/j.bbalip.2017.07.009. Epub 2017 Jul 25. PMID: 28754637; PMCID: PMC5595658.

Alternate Names

KIAA1881, MDRV, MRUPAV, NIPA2, S3-12

Entrez Gene IDs

729359 (Human); 57435 (Mouse); 363331 (Rat)

Gene Symbol

PLIN4

UniProt

Q96Q06 (Human)

Additional Perilipin-4 Products

Product Documents for Human Perilipin-4 Antibody (1114804) [Alexa Fluor™ Plus 680]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Perilipin-4 Antibody (1114804) [Alexa Fluor™ Plus 680]


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Protocols

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FAQs

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