Human PINK1 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB4357R Datasheet / COA / SDS

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FAB4357R-100UG

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Human PINK1 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human PINK1 in direct ELISAs.

Source

Monoclonal Rat IgG2a Clone # 420920

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PINK1
Met1-Leu581
Accession # ABM87645

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PINK1

PTEN-induced putative kinase 1 (PINK1) is a ubiquitous protein with highest levels in heart, skeletal muscle, and testis, and with lower expression in other tissues, including brain. PINK1 contains a mitochondrial targeting motif and a highly conserved protein kinase domain with strong homology to serine/threonine kinases of the calcium/calmodulin family. Mutations in the Pink1 gene have been identified as a cause of autosomal recessive early-onset parkinsonism.

Long Name

PTEN-induced Putative Kinase 1

Entrez Gene IDs

65018 (Human); 68943 (Mouse); 298575 (Rat); 3925520 (T. castaneum)

Alternate Names

BRPK; EC 2.7.11.1; FLJ27236; PARK6; Parkinson disease (autosomal recessive) 6; PINK1; protein kinase BRPK; PTEN Induced Kinase 1; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; serine/threonine-protein kinase PINK1, mitochondrial