Human PMEL Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB11439G Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB11439G-100UG

Save 15% on Select RUO Reagents. See Details.

All PMEL Antibodies

Product Details

Supplemental Products

Reviews

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human PMEL Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human PMEL in direct ELISA.

Source

Monoclonal Mouse IgG2b Clone # 1067144

Purification

Protein A or G purified

Immunogen

Chinese Hamster Ovary cell line, CHO-derived human PMEL
Lys25-Gln595
Accession # P40967

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PMEL

Premelanasome protein (PMEL) is a nonmutated "self" antigen expressed by melanocytes, most melanoma cells, substantia nigra, and retinal pigmented epithelium. This protein plays an essential role in the structural organization of premelanosomes. PMEL is over-expressed in all stages of melanoma progression and is negative prognostic marker for the overall survival rate of melanoma patients. PMEL is also associated with melanin-based pigmentation, neurodegenerative disease (functional amyloid) and glaucoma (missense mutations). How PMEL amyloid is tolerated within cells is of major therapeutic interest as it is related to Alzheimer's and Parkinson's disease.

Long Name

Premelanosome Protein

Entrez Gene IDs

6490 (Human); 20431 (Mouse)

Alternate Names

D12S53EP1; Gp100; ME20; ME20M; ME20-M; melanocyte protein mel 17; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; PMEL; PMEL17; PMEL17P100; premelanosome proteinME20M; SI; SIL; SILV; silver (mouse homolog) like; silver homolog (mouse); Silver locus protein homolog; silver, mouse, homolog of; SILVPmel17