Human/Rat PAK7 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB4696U Datasheet / COA / SDS

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FAB4696U-100UG

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Human/Rat PAK7 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Rat

Specificity

Detects human and rat PAK7 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 444703

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PAK7
Met1-Glu134
Accession # Q9P286

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PAK7

PAK7 (p21-activated kinase 7), also called PAK5, is a neuronal member of the PAK-II subfamily within the STE Ser/Thr protein kinase family. In the portion used as immunogen, human PAK7 shares 95% aa sequence identity with rat PAK7. This portion contains a CDC42/Rac1 interactive binding (CRIB) motif and potential phosphorylation sites at Ser104 and Thr107. In addition, PAK7 also interacts with RhoD and RhoH, directing its subcellular localization. PAK7 can be located in the mitochondrion, where it protects cells from apoptosis, or in the nucleus.

Long Name

p21/Cdc42/Rac1-activated Kinase 7

Entrez Gene IDs

57144 (Human); 241656 (Mouse); 311450 (Rat)

Alternate Names

PAK5; PAK7