Human S1P3/EDG-3 Alexa Fluor® 532-conjugated Antibody

Catalog #: FAB75241X Datasheet / COA / SDS

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FAB75241X-100UG

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All S1P3/EDG-3 Antibodies

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Human S1P3/EDG-3 Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human S1P₃/EDG‑3 in direct ELISAs.

Source

Monoclonal Mouse IgG2a Clone # 776807

Purification

Protein A or G purified

Immunogen

NS0 mouse myeloma cell line transfected with human S1P₃/EDGâ€‘3
Accession # Q99500

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: S1P3/EDG-3

EDG-3, also known as sphingosine 1-phosphate receptor-3 (S1P3), is a 378 amino acid (aa) seven-transmembrane receptor for the lysolipid phosphoric acid mediator, sphingosine 1-phosphate (S1P). EDG-3 interactions with S1P induce a range of responses including vasoconstriction, brachycardia, vascular endothelial and smooth muscle cell proliferation and migration, heart and liver fibrosis, and coagulation-induced inflammation. Extracellular portions of human EDG-3 show 74% aa identity with mouse and rat EDG-3.

Long Name

Endothelial Differentiation Gene 3

Entrez Gene IDs

1903 (Human); 13610 (Mouse); 306792 (Rat)

Alternate Names

EDG3; EDG-3; EDG3FLJ37523; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; LPB3; MGC71696; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; S1P3; S1PR3; sphingosine 1-phosphate receptor 3; Sphingosine 1-phosphate receptor Edg-3; sphingosine-1-phosphate receptor 3