Human SALL1 MAb (Clone K9814)

R&D Systems | Catalog # PP-K9814-00

R&D Systems
Discontinued Product
PP-K9814-00 has been discontinued. An alternative/replacement product is available: PP-K9814-0C. View all SALL1 products.

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)

Applications

Validated:

Immunohistochemistry, Western Blot, Immunoprecipitation

Cited:

Immunohistochemistry, Western Blot, Immunocytochemistry, Chromatin Immunoprecipitation (ChIP), Functional Assay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # K9814
View all SALL1 Primary Antibodies »

Product Specifications

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human SALL1 MAb (Clone K9814)

Detection of Human SALL1 by Immunocytochemistry/Immunofluorescence

Detection of Human SALL1 by Immunocytochemistry/Immunofluorescence

Stepwise differentiation of human iPSCs towards renal progenitor cells (RPCs).(a) Schematic description of the two-stage protocol applied to iPSC-renal commitment. (b, c, d, e) Immunofluorescence of iPSCs (derived from retroviral transfected dermal fibroblasts) exposed to differentiating media. (b) The pluripotency markers SSEA4, TRA-1-81, Nanog, ME marker T(Bry) and IM marker Osr1. (c) IM and MM marker expression as Wt1, Pax8, Pax2, Six2 and Sall1. (d) Renal progenitor markers CD133, CD24, NCAM, glomerular epithelial marker Claudin1 and proximal tubular epithelial markers AQP1, GGT1. (e) Markers identifying endodermal AFP, ectodermal Pax6, and cardiac mesodermal Nkx2.5 derivation. Nuclei are stained with DAPI (blue). Scale bars: 20 μm (b, c, d, e). Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/srep08826), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of Human SALL1 by Immunocytochemistry/ Immunofluorescence

Detection of Human SALL1 by Immunocytochemistry/ Immunofluorescence

Stepwise differentiation of human iPSCs towards renal progenitor cells (RPCs).(a) Schematic description of the two-stage protocol applied to iPSC-renal commitment. (b, c, d, e) Immunofluorescence of iPSCs (derived from retroviral transfected dermal fibroblasts) exposed to differentiating media. (b) The pluripotency markers SSEA4, TRA-1-81, Nanog, ME marker T(Bry) and IM marker Osr1. (c) IM and MM marker expression as Wt1, Pax8, Pax2, Six2 and Sall1. (d) Renal progenitor markers CD133, CD24, NCAM, glomerular epithelial marker Claudin1 and proximal tubular epithelial markers AQP1, GGT1. (e) Markers identifying endodermal AFP, ectodermal Pax6, and cardiac mesodermal Nkx2.5 derivation. Nuclei are stained with DAPI (blue). Scale bars: 20 μm (b, c, d, e). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/25744951), licensed under a CC-BY license. Not internally tested by R&D Systems.

Applications for Human SALL1 MAb (Clone K9814)

Application
Recommended Usage

Immunohistochemistry

Immunoprecipitation

Western Blot

Formulation, Preparation, and Storage

Formulation

A liquid formulation in physiologic saline with 0.1% NaN3.

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: SALL1

SALL1 (Sall-like Protein 1) is a member of the zinc finger Spalt-like protein family. It acts as a potential transcription repressor and may play a role in kidney development. Mutations have been shown to cause Townes-Brocks syndrome, an inherited disorder characterized by multiple birth defects including renal, ear, anal, and limb abnormalities.

Long Name

Sal-like 1

Alternate Names

HSal1, sal (Drosophila)-like 1, SAL1, Sal-1, sal-like 1 (Drosophila), sal-like protein 1, Spalt-like transcription factor 1, Zinc finger protein 794, Zinc finger protein SALL1, Zinc finger protein Spalt-1, ZNF794TBS

Entrez Gene IDs

6299 (Human)

Gene Symbol

SALL1

Additional SALL1 Products

Product Documents for Human SALL1 MAb (Clone K9814)

Certificate of Analysis

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Product Specific Notices for Human SALL1 MAb (Clone K9814)

For research use only

Related Research Areas

Transcription Factors

Citations for Human SALL1 MAb (Clone K9814)

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Protocols

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FAQs

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