Human Tensin 4/CTEN Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB6925S Datasheet / COA / SDS

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FAB6925S-100UG

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Human Tensin 4/CTEN Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Tensin 4/CTEN in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG1 Clone # 684524

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Tensin 4/CTEN
Ser2-Gln107
Accession # Q8IZW8

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Tensin 4/CTEN

CTEN, also known as Tensin 4, is a 90 kDa cytoplasmic protein that is associated with focal adhesions in epithelial cells and is upregulated in several carcinomas. It promotes tumorigenesis by disrupting the attachment of focal adhesions to the cytoskeleton, promoting epithelial-mesenchymal transition, and binding nuclear beta‑Catenin. CTEN is cleaved by Caspase-3 at Asp570-Ser571 during apoptosis. It contains a serine-rich region (aa 168-324), one SH2 domain (aa 449-556), and a phosphatase domain (aa 548-714). Within aa 1-107, human CTEN shares 62% and 59% aa sequence identity with mouse and rat CTEN, respectively.

Entrez Gene IDs

84951 (Human); 217169 (Mouse); 303517 (Rat)

Alternate Names

CTEN; CTENC terminal tensin like; C-terminal tensin-like protein; FLJ14950; Tensin 4; tensin-4; TNS4