Human TRIM38 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB9104S Datasheet / COA / SDS

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FAB9104S-100UG

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All TRIM38 Antibodies

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Human TRIM38 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human TRIM38 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 933011

Purification

Protein A or G purified

Immunogen

E.coli-derived recombinant human TRIM38
Leu190-Ile414
Accession # O00635

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TRIM38

Human Tripartite Motif 38 (TRIM38, RNF15) is a 465 aminoacids E3 ubiquitin ligase that plays a key role in tuning TLR-mediated immune responses by selectively targeting molecules in the TLR signaling for proteasomal degradation. The TRIM family of E3 ligases has more than 70 members in humans. Many members of this protein family are important immune regulators, mediating innate immune cell signal transduction and subsequent cytokine induction immune regulation. Trim38 deficiency, for example, greatly increases TLR3- and TLR4-mediated induction of type I Interferons and proinflammatory cytokines, such as TNF-alpha, IL-1 beta, and IL-6, in immune cells and in vivo.

Long Name

Tripartite Motif-containing 38

Entrez Gene IDs

10475 (Human); 214158 (Mouse); 680019 (Rat)

Alternate Names

MGC8946; RING finger protein 15RORETRo/SSA ribonucleoprotein homolog; RNF15; RoRet; TRIM38; tripartite motif containing 38; tripartite motif-containing 38; tripartite motif-containing protein 38; Zinc finger protein RoRet; zinc-finger protein RoRet