Human VIP Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB6079U Datasheet / COA / SDS

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FAB6079U-100UG

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Human VIP Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects recombinant human VIP in direct ELISAs. It does not detect the C-terminal region (aa 145-152).

Source

Monoclonal Mouse IgG1 Clone # 576721

Purification

Protein A or G purified

Immunogen

KLH-coupled human VIP synthetic peptides HSDAVFTDNYTR and KYLNSILN

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: VIP

Vasoactive intestinal peptide (VIP) is a 28 amino acid (aa) peptide that exerts wide-ranging effects in embryonic and adult tissues through interactions with the 7‑transmembrane spanning receptors VIP R1 and VIP R2. The VIP proprotein is proteolytically processed to release bioactive VIP as well as the bioactive peptides PHV and PHM. VIP regulates appetite and feeding behavior and stimulates insulin and glucagon secretion in pancreatic islet cells. It also regulates astrocyte function, multiple aspects of cardiac function, and TLR function in innate immune responses. Mature VIP shares 100% aa sequence identity with mouse and rat VIP.

Long Name

Vasoactive Intestinal Peptide

Entrez Gene IDs

7432 (Human)

Alternate Names

MGC13587; PHM27; vasoactive intestinal peptide; VIP peptides; VIP