JAB1 Antibody (OTI2B12)

Novus Biologicals | Catalog # NBP2-01813

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI2B12
View all JAB1 Primary Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human COPS5(NP_006828) produced in HEK293T cell.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

37.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for JAB1 Antibody (OTI2B12)

Western Blot: JAB1 Antibody (OTI2B12) [NBP2-01813]

Western Blot: JAB1 Antibody (OTI2B12) [NBP2-01813]

Western Blot: JAB1 Antibody (2B12) [NBP2-01813] - HEK293T cells were transfected with the pCMV6- ENTRY control (Left lane) or pCMV6-ENTRY COPS5 (RC200979, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with antiCOPS
Immunocytochemistry/ Immunofluorescence: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunocytochemistry/ Immunofluorescence: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunocytochemistry/Immunofluorescence: JAB1 Antibody (2B12) [NBP2-01813] - Anti-COPS5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY COPS5(RC200979).
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human kidney tissue. Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human tonsil within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human bladder tissue within the normal limits using antiCOPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human prostate tissue within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using antiCOPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human Ovary tissue within the normal limits using antiCOPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human lung tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human liver tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.
Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813]

Immunohistochemistry-Paraffin: JAB1 Antibody (OTI2B12) [NBP2-01813] - Staining of paraffin-embedded Human Kidney tissue within the normal limits. Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min.

Applications for JAB1 Antibody (OTI2B12)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:150

Immunohistochemistry-Paraffin

1:150

Western Blot

1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

0.76 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: JAB1

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq].

Long Name

Jun Activation Domain-binding Protein 1

Alternate Names

COPS5, CSN5, MOV-34, SGN5

Entrez Gene IDs

10987 (Human)

Gene Symbol

COPS5

UniProt

Q92905 (Human)

Additional JAB1 Products

Product Documents for JAB1 Antibody (OTI2B12)

Certificate of Analysis

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Product Specific Notices for JAB1 Antibody (OTI2B12)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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