LOX-1/OLR1 Antibody

Novus Biologicals | Catalog # NBP2-27298

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence

Cited:

Immunocytochemistry/ Immunofluorescence, IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all LOX-1/OLR1 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 150-210 of human LOX-1 was used as the immunogen for the antibody. (aa155-171)

Reactivity Notes

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LOX-1/OLR1 Antibody

Immunohistochemistry-Paraffin: LOX-1/OLR1 Antibody [NBP2-27298]

Immunohistochemistry-Paraffin: LOX-1/OLR1 Antibody [NBP2-27298]

Immunohistochemistry-Paraffin: LOX-1/OLR1 Antibody [NBP2-27298] - Formalin-fixed, paraffin-embedded human brain stained with LOX-1 antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen.

Applications for LOX-1/OLR1 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5-7ug/ml
Application Notes
Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min. Use in Immunohistochemistry and Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 27519944)/

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LOX-1/OLR1

CLEC8A, also called LOX-1 or OLR1, is one of the original C-Lectin type receptors (CLRs) associated with the fungal pattern recognition receptor Dectin-1. The DECTIN-1 associated clusters, including LOX-1, are found in the mammalian natural killer gene complex (NkC) (1). LOX-1 is an innate immune receptor expressed on a variety of cells including activated macrophages, platelets, smooth muscle endothelium and fibroblasts. Expression of LOX-1 is increased by pro-inflammatory milieus in autoimmune pathologies like diabetes or atherosclerosis or hyperlipidemia caused also by oxidative stress or oxLDL (2, 3). As activating immunoreceptors, CLRs are type II transmembrane proteins with a single CTLD, a C-type lectin-like domain that recognizes proteins and not carbohydrates (4). Antibody to LOX-1 is useful for functional, phenotyping or structural studies.

Long Name

Lectin-like Oxidized Low-density Lipoprotein Receptor 1

Alternate Names

CLEC8A, LOX1, OLR1, SCARE1, SR-E1

Gene Symbol

OLR1

UniProt

P78380

Additional LOX-1/OLR1 Products

Product Documents for LOX-1/OLR1 Antibody

Certificate of Analysis

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Product Specific Notices for LOX-1/OLR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for LOX-1/OLR1 Antibody

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Protocols

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