MMP-14/MT1-MMP Antibody (23GB2695)

Novus Biologicals | Catalog # NBP3-51165

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Rat

Applications

Western Blot, Flow Cytometry, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB2695
View all MMP-14/MT1-MMP Primary Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human MMP-14/MT1-MMP (Uniprot: P50281)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MMP-14/MT1-MMP Antibody (23GB2695)

MMP-14/MT1-MMP Antibody (23GB2695)

Flow Cytometry: MMP-14/MT1-MMP Antibody (23GB2695)[NBP3-51165] -

Flow cytometric analysis of MMP-14/MT1-MMPexpression in H9c2 cells using MMP-14/MT1-MMP antibody (1:2,000). Green, isotype control; red, Matrix metallopeptidase 14.
MMP-14/MT1-MMP Antibody (23GB2695)

Western Blot: MMP-14/MT1-MMP Antibody (23GB2695)[NBP3-51165] -

Western blotting analysis using MMP-14/MT1-MMP antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for MMP-14/MT1-MMP Antibody (23GB2695)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MMP-14/MT1-MMP

The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix (1). Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface (2). Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) (3).

Long Name

Matrix Metalloproteinase 14/Membrane Type 1 MMP

Alternate Names

MMP-X1, MMP14, MT-MMP1, MT1-MMP

Gene Symbol

MMP14

Additional MMP-14/MT1-MMP Products

Product Documents for MMP-14/MT1-MMP Antibody (23GB2695)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for MMP-14/MT1-MMP Antibody (23GB2695)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Metalloproteases and Regulators

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