Mouse NPRA/NPR1 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB3974V Datasheet / COA / SDS

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FAB3974V-100UG

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All NPRA/NPR1 Antibodies

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Mouse NPRA/NPR1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse NPRA/NPR1 in direct ELISAs.

Source

Monoclonal Rat IgG2a Clone # 488620

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse NPRA/NPR1
Ser29-Glu469 (predicted)
Accession # P18293

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NPRA/NPR1

Mouse NPR1 (natriuretic peptide receptor-1; also ANP-R1 or guanlyl cyclase-A) is a 130 kDa member of the guanylyl cyclase family of proteins. It is a type I transmembrane glycoprotein that contains a 441 aa extracellular domain (ECD) (aa 29‑469) and a 567 aa cytoplasmic region. The cytoplasmic region shows a tyrosine kinase and guanylyl cyclase catalytic domain. NPR1 operates as an oligomer and binds both ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide). ANP binding induces bronchodilation and a reduction in blood pressure. Over aa 29‑469, mouse NPR1 is 97% and 86% aa identical to rat and human NPR1, respectively.

Long Name

Natriuretic Peptide Receptor A

Entrez Gene IDs

4881 (Human); 18160 (Mouse); 24603 (Rat)

Alternate Names

ANPa; ANP-A; ANPRA; ANPR-A; ANPRAEC 4.6.1.2; atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; GC-A; Guanylate cyclase A; GUC2A; GUCY2A; natriuretic peptide A type receptor; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptidereceptor A); NPR1; NPRA; NPR-A; Pndr