Mouse PLA2G2A Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: PLA2G2A

Secretory Phospholipase A₂ is an enzyme that hydrolyses the sn-2 ester bond of phospholipids, generating non-esterified free fatty acids and lysophospholipids (1‑3). PLA2G2A is a calcium-dependent phospholipase expressed in many cell types participating in inflammation-associated cellular responses, including platelets, neutrophils, and mast cells. It may function as an enzymatic component of the host defense mechanism. For example, human tears contain a high concentration of PLA2G2A, a principal bactericidal factor against Gram-positive bacteria in this fluid. It may play a role in cell proliferation through binding a receptor on the cell membrane. PLA2G2A has been shown to have pro-atherogenic properties both in the circulation and within the arterial wall (4). It is an acute phase protein expressed in response to a variety of pro-inflammatory cytokines. Circulating levels of sPLA2G2A are higher in coronary artery disease (CAD) patients and are associated with increased risk of future CAD (5).

Product Datasheets

Related Research Areas

• Acute Phase Proteins
• Alpha Granule Soluble Molecules
• Bioactive Lipids and Receptors
• Enzymes Secreted by Endothelial Cells
• Lipid/Cholesterol Metabolism Enzymes
• Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
• Steroid Hormones and Bioactive Lipids