Mouse SEZ6L2/BSRP-A Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB4916N Datasheet / COA / SDS

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FAB4916N-100UG

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Mouse SEZ6L2/BSRP-A Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse SEZ6L2/BSRP-A in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) BSRP‑B or rmBSRP‑C is observed.

Source

Monoclonal Rat IgG2a Clone # 529805

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse SEZ6L2/BSRP-A
Leu28-Ser837
Accession # Q4V9Z5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SEZ6L2/BSRP-A

BSRP-A (Brain-specific receptor-like protein A; also known as SEZ6L2) is a 170 kDa member of the BSRP family of proteins. It is expressed in the plasma membrane and ER of CNS neurons, and likely regulates PKC alpha activation. Mature mouse BSRP-A is an 890 amino acid (aa) type I transmembrane protein. It contains an 824 aa extracellular domain (ECD) (aa 21-844) and a 43 aa cytoplasmic tail. The ECD shows two CUB domains and five short consensus repeats (SCRs). There are multiple isoforms for BSRP-A. One shows a premature truncation after Arg403, a second shows a deletion of aa 71-130, and a third likely represents the full-length form that contains a 13 aa insertion after Val830. Over aa 28-837, mouse BSRP-A shares 96% and 99% aa sequence identity with human and rat BSRP-A, respectively.

Long Name

Seizure Related 6 Homolog-Like 2/Brain-specific Receptor-like Protein-A

Entrez Gene IDs

26470 (Human); 233878 (Mouse); 308988 (Rat)

Alternate Names

BSRPA; BSRP-A; PSK-1; seizure 6-like protein 2; seizure related 6 homolog (mouse)-like 2; SEZ6L2; UNQ1903/PRO4349