Mouse u-Plasminogen Activator (uPA)/Urokinase Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: u-Plasminogen Activator (uPA)/Urokinase

Urokinase-type plasminogen activator (uPA) is a 378 amino acid enzyme which cleaves the zymogen plasminogen to form the active enzyme plasmin. uPa occurs in high and low molecular mass forms each consisting of two chains (A and B).  The high mass form has a long A chain while the low mass form has a short chain AuPA is widely expressed in normal tissues including epithelia, muscle, reproductive organs and brain, and  is highly expressed in kidney, where it localizes to proximal and distal tubules and is secreted into urine. uPA is known to play a role in wound healing and  tissue remodeling and  tumor invasion

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• Coagulation
• Complement Pathway
• Extracellular Matrix Remodeling and Cell Migration During EMT
• Inflammatory Mediators
• Plasmin/Plasminogen and Kallikrein/Kinin Systems
• Proteolytic Degradation of Amyloid beta
• Serine Proteases and Regulators
• Transport of Amyloid beta Across the Blood-Brain Barrier