PRCC Antibody

Novus Biologicals | Catalog # NBP3-29227

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all PRCC Primary Antibodies »

Product Specifications

Immunogen

Between 125 and 175

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PRCC Antibody

PRCC Antibody

Immunohistochemistry:[NBP3-29227]-

Immunohistochemistry:[NBP3-29227]-Detection of human PRCC by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PRCC.

Applications for PRCC Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-buffered Saline 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: PRCC

In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.

Alternate Names

MGC17178, papillary renal cell carcinoma (translocation-associated), Papillary renal cell carcinoma translocation-associated gene protein, proline-rich protein PRCC, RCCP1MGC4723, TPRC

Gene Symbol

PRCC

Additional PRCC Products

Product Documents for PRCC Antibody

Certificate of Analysis

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Product Specific Notices for PRCC Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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