AI Modified Proteins: R&D Systems

Proteins Designed For Performance

Designed for Thermal Stability

Designed for Efficiency

Designed for Affinity

Designed for Hyperactivity

Sample Request

Overcome Cell Culture Challenges with R&D Systems AI Modified Proteins

Discover the future of protein design with R&D Systems designer proteins, an advanced solution to overcome cell culture challenges. Engineered using cutting-edge technologies such as generative AI (artificial intelligence), protein library evolution, and rational design, these innovative proteins deliver critical benefits resulting in enhanced cell culture performance, including:

Optimized cell expansion
Longer stability in media
Superior biological activity
Streamlined workflows and a path to clinical applications

Our state-of-the-art designer proteins mirror the biological functionality of their wild-type counterparts while introducing optimized features to meet the evolving demands of cell therapy workflows and research applications.

With tailored functionalities such as hyperactivity, improved receptor affinities, enhanced workflow efficiency, and heat stability, our new designer cytokines and growth factors represent a breakthrough in cell culture innovation.

Proteins Designed for Thermal Stability

Engineered for stability at high temperatures, our heat stable proteins maintain high bioactivity in cell culture for longer periods than the corresponding wild-type protein.

Heat Stable Proteins

Ideal for cell therapy applications, heat stable proteins ensure:

Improved Stability: Higher activity retention than wild-type counterparts, able to withstand high temperatures and extended culture durations
Consistent Cultures: Increased stability in media over extended durations allows for greater consistency throughout cell culture workflows
Reliable Performance: Heat Stable IL-2 promotes CD8⁺/CD4⁺ T cell outgrowth similar to the standard IL-2 protein, with comparable T cell phenotypes
Seamless Path to Clinic: Our research-grade, Animal-free Preclinical, and GMP-grade FGF basic Heat Stable Proteins show equivalent bioactivity, ensuring performance continuity from research to clinical applications

IL-2 Heat Stable Agonist Protein FGF basic Heat Stable Protein FGF-10 Heat Stable Protein

Proteins Designed for Efficiency

Engineered to be water-soluble and easier to purify, our Wnt/R-Spondin Agonist Proteins effectively activate canonical Wnt signaling.

Wnt/R-Spondin Agonist Proteins

Key reagents for advancing stem cell research, organoid development, and regenerative medicine, these proteins offer:

All-in-One Activation: Reduce experimental complexity with a single, cost-effective protein
Streamline Workflows: Save time with a well-defined reagent to substitute for conditioned media or the addition of two individual proteins
Reliable Performance: Effectively promotes Wnt receptor activation and canonical Wnt signaling
Increased Solubility: More amenable to media formulations than traditional Wnt proteins

Wnt/R-Spondin Agonist Proteins

Proteins Designed for Affinity

Engineered to engage target receptors with higher affinity, these proteins show improved binding and cell expansion compared to their standard protein counterparts.

IL-2 (CD122-Directed) Protein

Ideal for large scale CAR T-cell or TIL expansion, this protein ensures:

Enhanced CD122 Binding: Displays increased affinity to the IL-2 beta receptor (CD122) with decreased affinity to the IL-2 alpha receptor (CD25), resulting in more effective expansion of effector T cells
Improved Output: Maintains growth of CD8⁺/CD4⁺ T cells for workflows requiring extended T cell proliferation
Sustained Potential: Improved proliferation capacity and enhanced naive population without increased exhaustion of T cells

IL-2 (CD122-Directed) Protein

Proteins Designed for Hyperactivity

Engineered for enhanced bioactivity, hyperactive proteins demonstrate superior performance compared to the corresponding wild-type protein.

Activin A Hyperactive Protein

Optimized for superior performance in regenerative medicine cell differentiation applications, this protein gives:

Enhanced Activity: Cost-effective protein provides 4-fold higher activity than the wild-type Activin A protein, allowing less protein to be used to achieve the same potency
Confidence in Performance: Promotes efficient endoderm differentiation in human iPSC lines
Reliable Results: Efficient derivation of PDX1⁺/NKX6.1⁺ pancreatic progenitors that is comparable to the wild-type protein

Activin A Hyperactive Protein

AI Modified Protein Sample Request

R&D Systems is now offering free samples of our AI Modified Proteins. Please fill out the form below and specify which AI Modified Protein you are interested in testing. A team member will reach out to confirm shipping and send you a sample of the designated protein while supplies last. Interested in sampling more than one AI Modified Protein? Let us know in the Comments box.

View All AI Modified Proteins

Heat Stable Proteins	Efficient Proteins	Affinity Proteins	Hyperactive Proteins
RUO FGF basic Heat Stable: Catalog # BT-FGFBHS	Wnt/RSPO1 Agonist: Catalog # BT-WRSP1	IL-2 (CD122-Directed): Catalog # BT-002DBR	Activin A Hyperactive: Catalog # BT-ACTAH
Animal-free Preclinical FGF basic Heat Stable: Catalog # BT-FGFBHS-AFL	Wnt/RSPO2 Agonist: Catalog # BT-WRSP2
GMP FGF basic Heat Stable: Catalog # BT-FGFBHS-GMP	Wnt/RSPO3 Agonist: Catalog # BT-WRSP3
FGF-10 Heat Stable: Catalog # BT-FGF10HS
IL-2 Heat Stable Agonist: Catalog # BT-002HS