Rat RTN1-A/NSP Alexa Fluor® 532-conjugated Antibody

Catalog #: FAB5996X Datasheet / COA / SDS

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FAB5996X-100UG

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All RTN1-A/NSP Antibodies

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Rat RTN1-A/NSP Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Rat

Specificity

Detects rat RTN1-A/NSP in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant rat RTN-A2B, recombinant human (rh) RTN1-A, and rhRTN3-A1 is observed.

Source

Monoclonal Mouse IgG1 Clone # 559706

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant rat RTN1-A/NSP
Met73-Ser502
Accession # Q64548

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: RTN1-A/NSP

Reticulon-1 (RTN1-A/RTN1) is a 135 kDa multi-pass membrane protein localized to the endoplasmic reticulum of neurons. RTN1-A belongs to no known family of proteins. Rat RTN1-A is 777 amino acids (aa) in length and contains two transmembrane segments and a Reticulon domain (aa 592-759). There are also multiple potential sites for phosphorylation. Alternative splicing produces a second isoform known as RTN1-S, which is missing residues corresponding to aa 1-569 in RTN1-A, and has a 20 aa substitution for residues corresponding to aa 570-589. Rat RTN1-A is 82% aa identical to human RTN1-A

Long Name

Reticulon 1A/Neuroendocrine-specific Protein

Entrez Gene IDs

6252 (Human); 116644 (Rat)

Alternate Names

NSP; NSP-A; RTN1; RTN1A; RTN1-A