Syntrophin alpha 1 Antibody - BSA Free

Novus Biologicals | Catalog # NB600-1324

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Syntrophin alpha 1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to the N-terminal sequence of human alpha 1 syntrophin (amino acids 2-18 with C-terminally added lysine) conjugated to KLH.

Reactivity Notes

Cross-reacts with Human and Rat. Expected to cross-react with Mouse due to sequence identity. Not yet tested in other species.

Localization

Membrane-associated. In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.

Specificity

Syntrophin alpha 1

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Syntrophin alpha 1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:1000
Application Notes
IHC: Dilution determined by using paraformaldehyde-fixed, Triton X-100 treated, frozen sections of rat skeletal muscle.WB: Dilution determined using a membrane fraction extract of rat skeletal muscle homogenate. Staining of alpha 1 syntrophin is specifically inhibited with alpha 1 syntrophin immunizing peptide. Predicted molecular weight: 60 kDa.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

10mM PBS (pH 7.4)

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

9.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Syntrophin alpha 1

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes.

Alternate Names

59 kDa dystrophin-associated protein A1 acidic component 1, dJ1187J4.5, LQT12, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, SNT1alpha-1-syntrophin, syntrophin, alpha 1 (dystrophin-associated protein A1, 59kD, acidic component), syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component), syntrophin-1, TACIP1acidic alpha 1 syntrophin

Entrez Gene IDs

362242 (Rat)

Gene Symbol

SNTA1

Additional Syntrophin alpha 1 Products

Product Documents for Syntrophin alpha 1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Syntrophin alpha 1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs for Syntrophin alpha 1 Antibody - BSA Free

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  • Q: I would like to order a syntrophin antibody to use in drosophila fly model. Drosophila genome has only two syntrophins (when humans have 5). I am interested in syntrophin1 which is homologous to human syntrophins alpha 1, beta 1 and 2. You say on the website that you have monoclonal syntrophin alpha 1 antibody. Do you have information against which syntrophin peptide this antibody works? I need to make sure that this specific clone that you cell on the website would recognize syntrophin 1 in drosophila. For this I need to make sure that the peptide against which the a/b works is conserved. If this is possible, I would like to know all the syntrophins alpha and beta peptides against which you have antibodies available. Then I can find among those the peptide which is conserved in drosophila and order that specific antibody. Like here NBP2-03302. It is written that the antibody was produced using the whole syntrophin protein for immunization. But the final a/b on sale is monoclonal. As understand, it means that you selected a specific clone, that recognizes a specific peptide in the syntrophin gene. Is there information available to which peptide this a/b is?

    A: Depending on the particular antibody, different amounts of information are available about the immunogen and epitope. Sometimes, we cannot disclose details of the immunogen, because it is proprietary information. Sometimes we have not carried out epitope mapping, and are not sure of the epitope. For other antibodies, we know more or can disclose more information. The following antibodies include details of immunogen amino acid sequence on the website data sheet: NB100-1346, NB100-1364, NB600-1324, NBP1-59784. If you require more details about the immunogen/epitope of these or any of the other antibodies, I can make enquiries for you, but as discussed above I may not be able to provide further details

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