TRPM6 Antibody (RB3407)

Novus Biologicals | Catalog # NBP3-52272

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG Clone # RB3407
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Product Specifications

Immunogen

This TRPM6 (CHAK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-348 amino acids from the Central region of human TRPM6 (CHAK2).(Accession#:NP_001170781.1;NP_001170782.1;NP_060132.3)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRPM6 Antibody (RB3407)

TRPM6 Antibody (RB3407)

Western Blot:TRPM6 Antibody (RB3407)[NBP3-52272]-

CHAK2 Antibody (H332) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CHAK2 antibody detected the CHAK2 protein (arrow).
TRPM6 Antibody (RB3407)

Immunohistochemistry-Paraffin:TRPM6 Antibody (RB3407)[NBP3-52272]-

CHAK2 Antibody (H332) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CHAK2 antibody detected the CHAK2 protein (arrow).

Applications for TRPM6 Antibody (RB3407)

Application
Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

PBS

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRPM6

FUNCTION: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells).; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in H510 small cell lung carcinoma cells.

Alternate Names

CHAK2HMGX, Channel kinase 2, EC 2.7.11.1, FLJ22628, HOMG, HOMG1, HSH, hypomagnesemia, secondary hypocalcemia, Melastatin-related TRP cation channel 6, transient receptor potential cation channel subfamily M member 6, transient receptor potential cation channel, subfamily M, member 6

Gene Symbol

TRPM6

Additional TRPM6 Products

Product Documents for TRPM6 Antibody (RB3407)

Certificate of Analysis

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Product Specific Notices for TRPM6 Antibody (RB3407)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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