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86 results for "GSK-3 alpha/beta" in 产品
GSK-3 alpha/beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
GMP Version Available:
TB4423-GMP
GMP
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% |
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| Reactivity: | Human |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Flow, ICC/IF, CyTOF-ready |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SY26-05 |
| Applications: | IHC, WB, ICC/IF, IP |
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| Chemical Name: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% |
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| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2B Monoclonal Clone #833916 |
| Applications: | WB, ICC/IF |
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| Chemical Name: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% |
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| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% |
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| Reactivity: | Human, Mouse, Rat, Porcine, Bovine, +5 More |
| Details: | Mouse IgG2B Monoclonal Clone #1H8 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 alpha/beta Antibody (1H8) [NB110-85523]](https://resources.rndsystems.com/images/products/GSK-3-alpha-beta-Antibody-1H8-Western-Blot-NB110-85523-img0003.jpg "Western Blot: GSK-3 alpha/beta Antibody (1H8) [NB110-85523]")
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| Reactivity: | Human, Mouse, Rat |
| Assay Range: | 156-10000 pg/mL |
| Applications: | ELISA |
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| Chemical Name: | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
| Purity: | ≥98% |
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| Chemical Name: | 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole |
| Purity: | ≥98% |
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| Chemical Name: | N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea |
| Purity: | ≥98% |
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| Chemical Name: | 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea |
| Purity: | ≥98% |
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| Alternate Names: | NP 01139 |
| Chemical Name: | 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione |
| Purity: | ≥98% |
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| Chemical Name: | 3-Amino-6-(4-((4-(4-(1-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)butyl)piperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide |
| Purity: | ≥98% |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR1908 |
| Applications: | IHC, WB, ICC/IF, IP |
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| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥97% |
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| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, IP |
![Western Blot: GSK-3 alpha/beta [p Ser21] AntibodyAzide and BSA Free [NBP3-05443]](https://resources.rndsystems.com/images/products/GSK-3-alpha-beta-[p-Ser21]-Antibody-Western-Blot-NBP3-05443-img0003.jpg "Western Blot: GSK-3 alpha/beta [p Ser21] AntibodyAzide and BSA Free [NBP3-05443]")
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #23GB4380 |
| Applications: | WB, Flow, ICC/IF, Mycoplasma |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #23GB1100 |
| Applications: | WB, Flow, ICC/IF, Mycoplasma |
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Human/Mouse/Rat Phospho-GSK‑3 alpha / beta (S21/S9) Alexa Fluor® 488‑conjugated Antibody
Catalog #:
AF1590G
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
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Human/Mouse/Rat Phospho-GSK‑3 alpha / beta (S21/S9) Alexa Fluor® 700‑conjugated Antibody
Catalog #:
AF1590N
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
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Human/Mouse/Rat Phospho-GSK‑3 alpha / beta (S21/S9) Alexa Fluor® 647‑conjugated Antibody
Catalog #:
AF1590R
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
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