5 results for "Inward Rectifier Potassium Channel Activators Small Molecules and Peptides" in 产品
Inward Rectifier Potassium Channel Activators Small Molecules and Peptides
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).
Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.
Kir6 channel (KATP) opener
| Chemical Name: | 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide |
| Purity: | ≥98% |
Kir6 (KATP) channel opener; active enantiomer of Cromakalim
| Alternate Names: | BRL 38227 |
| Chemical Name: | (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile |
| Purity: | ≥98% |
Selective Kir3.1/3.2 (GIRK1/2) channel activator
| Chemical Name: | N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea |
| Purity: | ≥98% |
Selective activator of SUR1 Kir6.2 channels
| Chemical Name: | 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| Purity: | ≥98% |
Selective inhibitor of Kir6.1 KATP channels
| Chemical Name: | 1-[(4-Methyl-2-thiophen-2-yl-1,3-thiazol-5-yl)methyl]-3-thiophen-2-ylurea |
| Purity: | ≥98% |
