12 results for "mTOR Inhibitors Small Molecules and Peptides" in 产品
mTOR Inhibitors Small Molecules and Peptides
mTOR (mechanistic Target Of Rapamycin, mammalian Target Of Rapamycin aka FRAP, FK506 binding protein 12 (FKBP12)-rapamycin associated protein 1) plays a key role in coordinating the signals for a number of pathways, including insulin signaling, nutrient sensing and mitogenic signaling. mTOR is a large (>280kD), multidomain protein that includes a kinase domain and a FKBP12 binding domain. Rapamycin binds to FKBP12 and then complexes with mTOR to inhibit the enzyme.
The PI 3-K pathway ...
Potent and selective mTOR inhibitor
| Chemical Name: | 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Purity: | ≥98% |
mTOR inhibitor; immunosuppressant
| Chemical Name: | (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone |
| Purity: | ≥98% |
mTOR inhibitor; Immunosuppressant
| Alternate Names: | RAD001 |
| Chemical Name: | 42-O-(2-Hydroxyethyl)rapamycin |
| Purity: | ≥98% |
Selective mTOR inhibitor
| Chemical Name: | rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol |
| Purity: | ≥97% |
Inhibitor of PI 3-kinase, mTOR and DNA-PK
| Chemical Name: | 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride |
| Purity: | ≥97% |
STAT3 inhibitor; also inhibits mTORC1 signaling
| Chemical Name: | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
| Purity: | ≥98% |
Potent and selective mTOR inhibitor
| Chemical Name: | 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Purity: | ≥98% |
Dual mTORC1/mTORC2 inhibitor
| Chemical Name: | 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol |
| Purity: | ≥98% |
mTOR inhibitor; antitumor
| Alternate Names: | CCI-779 |
| Chemical Name: | Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate] |
| Purity: | ≥98% |
Potent and selective mTOR inhibitor
| Chemical Name: | N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride |
| Purity: | ≥98% |
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
| Alternate Names: | GSK2126458 |
| Chemical Name: | 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide |
| Purity: | ≥98% |
Highly potent and selective mTOR inhibitor
| Chemical Name: | 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol |
| Purity: | ≥98% |
