Catalog Number: 1624
Alternate Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP
Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Biological Activity
Potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets.
    Macfarlane et al.
    J.Clin.Invest., 1983;71:420
  2. A retrospective of recombinant P2Y receptor subtypes and their pharmacology.
    Sak and Webb
    Arch.Biochem.Biophys., 2002;397:131
  3. P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse.
    Zhang et al.
    J.Pharmacol.Exp.Ther., 2002;301:705
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