2-Methylthioadenosine diphosphate trisodium salt

  ( 7 citations )    
Product Datasheet
Catalog Number:1624
Alternate Names:2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP
Chemical Name:2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity
Potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.
Technical Data
  • M.Wt:
    539.24
  • Formula:
    C11H14N5Na3O10P2S
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    475193-31-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

7 Citations: Showing 1 - 7
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  1. Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.
    Authors: Modjeski Et al.
    PLoS One  2016;11:e0160638
  2. Agonist-bound structure of the human P2Y12 receptor.
    Authors: Zhang Et al.
    Purinergic Signal  2014;509:119
  3. The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
    Authors: Voss Et al.
    Br J Pharmacol  2014;10:455
  4. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  5. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
    Authors: Yamanaka Et al.
    PLoS One  2012;7:e45032
  6. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    Nature  2012;5:ra26
  7. Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets.
    Authors: Ohtani Et al.
    Purinergic Signal  2008;4:365

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