2-Methylthioadenosine diphosphate trisodium salt

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2-Methylthioadenosine diphosphate trisodium salt | CAS No. 475193-31-8 | P2Y Receptor Agonists
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Description: Potent agonist at P2Y1, P2Y12 and P2Y13
Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP

Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

Purity: ≥98%

Product Details
Citations (12)
Supplemental Products
Reviews

Biological Activity

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data

M.Wt:
539.24
Formula:
C11H14N5Na3O10P2S
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
475193-31-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 2-Methylthioadenosine diphosphate trisodium salt

The citations listed below are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

12 Citations: Showing 1 - 10

  1. Platelet-derived β2M regulates monocyte inflammatory responses.
    Authors: Hilt Et al.
    JCI Insight  2019;4
  2. P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development.
    Authors: Zhang Et al.
    Front Cell Neurosci  2019;13:152
  3. The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.
    Authors: Lu Et al.
    Front Pharmacol  2018;9:242
  4. Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
    Authors: Madry Et al.
    Neuron  2018;97:299
  5. PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
    Authors: Manne Et al.
    J Thromb Haemost  2018;16:1211
  6. Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.
    Authors: Modjeski Et al.
    PLoS One  2016;11:e0160638
  7. Agonist-bound structure of the human P2Y12 receptor.
    Authors: Zhang Et al.
    Purinergic Signal  2014;509:119
  8. The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
    Authors: Voss Et al.
    Br J Pharmacol  2014;10:455
  9. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  10. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
    Authors: Yamanaka Et al.
    PLoS One  2012;7:e45032

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