2-Methylthioadenosine diphosphate trisodium salt

Name: 2-Methylthioadenosine diphosphate trisodium salt
Brand: Tocris Bioscience
SKU: 1624
Price: 426 USD
Availability: InStock

Tocris Bioscience | Catalog # 1624

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Citations (26)

Product Documents

Potent agonist at P2Y1, P2Y12 and P2Y13

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent agonist at P2Y1, P2Y12 and P2Y13

Alternative Names

2-(Methylthio)adenosine 5'-diphosphate,2-Methylthio-ADP,MeSADP

View all P2Y Receptor Agonists »

Product Description

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y₁, P2Y₁₂ and P2Y₁₃ receptors (pEC₅₀ = 8.29 and 9.05 for P2Y₁ and P2Y₁₂, EC₅₀ = 19 nM for P2Y₁₃). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Product Specifications for 2-Methylthioadenosine diphosphate trisodium salt

Molecular Weight

539.24

Formula

C₁₁H₁₄N₅Na₃O₁₀P₂S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

CAS Number

475193-31-8

PubChem ID

52942441

InChI Key

DYNGCIHMNWOBSU-MSQVLRTGSA-K

SMILES

O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N3C2=NC(SC)=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Sak and Webb A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 2002 PMID: 11747319
Zhang P2Y₁₃: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 2002 PMID: 11961076
Macfarlane 2-Methylthioadenosine[β-³²P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 1983 PMID: 6298277

Product Documents for 2-Methylthioadenosine diphosphate trisodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for 2-Methylthioadenosine diphosphate trisodium salt

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Citations for 2-Methylthioadenosine diphosphate trisodium salt

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