2-Methylthioadenosine diphosphate trisodium salt
Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Biological Activity2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets.
Macfarlane et al.
P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse.
Zhang et al.
A retrospective of recombinant P2Y receptor subtypes and their pharmacology.
Sak and Webb
Citations for 2-Methylthioadenosine diphosphate trisodium salt
The citations listed below are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:
12 Citations: Showing 1 - 10
Platelet-derived β2M regulates monocyte inflammatory responses.
Authors: Hilt Et al.
JCI Insight 2019;4
P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development.
Authors: Zhang Et al.
Front Cell Neurosci 2019;13:152
The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.
Authors: Lu Et al.
Front Pharmacol 2018;9:242
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
Authors: Madry Et al.
PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
Authors: Manne Et al.
J Thromb Haemost 2018;16:1211
Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.
Authors: Modjeski Et al.
PLoS One 2016;11:e0160638
Agonist-bound structure of the human P2Y12 receptor.
Authors: Zhang Et al.
Purinergic Signal 2014;509:119
The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
Authors: Voss Et al.
Br J Pharmacol 2014;10:455
Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
Authors: Yamanaka Et al.
PLoS One 2012;7:e45032
Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
Authors: Wang Et al.
Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and Ins secretion in mouse pancreatic islets.
Authors: Ohtani Et al.
Purinergic Signal 2008;4:365
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