2-Methylthioadenosine diphosphate trisodium salt (CAS 475193-31-8): R&D Systems
Catalog Number: 1624
Alternate Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP
Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Biological Activity
Potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.
Technical Data
  • M.Wt:
    539.24
  • Formula:
    C11H14N5Na3O10P2S
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    475193-31-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets.
    Macfarlane et al.
    J.Clin.Invest., 1983;71:420
  2. A retrospective of recombinant P2Y receptor subtypes and their pharmacology.
    Sak and Webb
    Arch.Biochem.Biophys., 2002;397:131
  3. P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse.
    Zhang et al.
    J.Pharmacol.Exp.Ther., 2002;301:705
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

6 Citations: Showing 1 - 6
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  1. Agonist-bound structure of the human P2Y12 receptor.
    Authors: Zhang Et al.
    Purinergic Signal 2014;509:119
  2. The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
    Authors: Voss Et al.
    Br J Pharmacol 2014;10:455
  3. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol 2013;305:C1050
  4. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
    Authors: Yamanaka Et al.
    PLoS One 2012;7:e45032
  5. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    Nature 2012;5:ra26
  6. Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets.
    Authors: Ohtani Et al.
    Purinergic Signal 2008;4:365

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