7-Chlorokynurenic acid sodium salt

Tocris Bioscience | Catalog # 3697

Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
Tocris Bioscience

Key Product Details

Description

Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
View all Glutamate (EAAT) Transporter Inhibitors »

Product Description

7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Product Specifications for 7-Chlorokynurenic acid sodium salt

Molecular Weight

245.59

Formula

C10H5ClNNaO3

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt

CAS Number

1263094-00-3

PubChem ID

52974249

InChI Key

IFZYIORLNGNLEI-UHFFFAOYSA-M

SMILES

[Na+].OC1=CC(=NC2=CC(Cl)=CC=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.56 100

Preparing Stock Solutions for 7-Chlorokynurenic acid sodium salt

The following data is based on the product molecular weight 245.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.07 mL 20.36 mL 40.72 mL
5 mM 0.81 mL 4.07 mL 8.14 mL
10 mM 0.41 mL 2.04 mL 4.07 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for 7-Chlorokynurenic acid sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 7-Chlorokynurenic acid sodium salt

For research use only

Citations for 7-Chlorokynurenic acid sodium salt

Customer Reviews for 7-Chlorokynurenic acid sodium salt (1)

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  • Successful block of ion flow through NMDA receptors
    Name: Anonymous
    Assay Type: In Vitro
    Cell Line/Tissue: Organotypic Hippocampus Slices
    Verified Customer | Posted 10/20/2017
    We incubate with this drug for at least 30 minutes before use. We are using cultured hippocampus slices.
    We used this drug in bath application to block ion flow through NMDA receptors and observe dendritic spine structural plasticity int he absence of ion flow.
    7-Chlorokynurenic acid sodium salt 3697

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