7-Chlorokynurenic acid sodium salt

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3697/10
3697/50
7-Chlorokynurenic acid sodium salt | CAS No. 1263094-00-3 | Glutamate (EAAT) Transporter Inhibitors
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Description: Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)

Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt

Purity: ≥98%

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Biological Activity

Sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Technical Data

M.Wt:
245.59
Formula:
C10H5ClNNaO3
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1263094-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
    Kretschmer et al.
    Eur.J.Pharmacol., 1995;280:37
  2. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
    Bartlett et al.
    Neuropharmacology, 1998;37:839
  3. 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
    Kemp et al.
    Proc.Natl.Acad.Sci.USA, 1988;85:6547
  4. Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain.
    Donald et al.
    Br.J.Pharmacol., 1988;95:892P

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