7-Chlorokynurenic acid sodium salt
Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Biological Activity7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.
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Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
Kretschmer et al.
Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
Bartlett et al.
7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
Kemp et al.
Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain.
Donald et al.
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We used this drug in bath application to block ion flow through NMDA receptors and observe dendritic spine structural plasticity int he absence of ion flow.
We incubate with this drug for at least 30 minutes before use. We are using cultured hippocampus slices.