Catalog Number: 3697
Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Biological Activity
Sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.
Technical Data
  • M.Wt:
    245.59
  • Formula:
    C10H5ClNNaO3
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1263094-00-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
    Bartlett et al.
    Neuropharmacology, 1998;37:839
  2. Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
    Kretschmer et al.
    Eur.J.Pharmacol., 1995;280:37
  3. 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
    Kemp et al.
    Proc.Natl.Acad.Sci.USA, 1988;85:6547
Tocris Small Molecules
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7-Chlorokynurenic acid

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 Successful block of ion flow through NMDA receptors 3697
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  Anonymous 10/20/2017
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 Successful block of ion flow through NMDA receptors 3697
: Successful block of ion flow through NMDA receptors [3697]

Other Experimental Details

Other Experimental DetailsWe incubate with this drug for at least 30 minutes before use. We are using cultured hippocampus slices.

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