7-Chlorokynurenic acid

Key Product Details

Product Description

7-Chlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Sodium Salt also available.

Product Specifications for 7-Chlorokynurenic acid

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 7-Chlorokynurenic acid

The following data is based on the product molecular weight 223.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

7 6 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.47 mL	22.36 mL	44.72 mL
5 mM	0.89 mL	4.47 mL	8.94 mL
10 mM	0.45 mL	2.24 mL	4.47 mL
50 mM	0.09 mL	0.45 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

• Donald Characterization of [³H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol.
• Kemp 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.U.S.A. 1988 PMID: 2842779
• Kretschmer Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 1995 PMID: 7498252
• Bartlett Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 1998 PMID: 9776380

Product Documents for 7-Chlorokynurenic acid