Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Biological Activity7-Chlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.
Sodium Salt also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
Kretschmer et al.
Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
Bartlett et al.
7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
Kemp et al.
Characterization of [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain.
Donald et al.
Citations for 7-Chlorokynurenic acid
The citations listed below are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid include:
6 Citations: Showing 1 - 6
NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
Authors: Biase Et al.
Proc Natl Acad Sci U S A 2011;31:12650
White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
Authors: Baltan Et al.
J Neurosci 2008;28:1479
Differential compartmentalization and distinct functions of GABAB receptor variants.
Authors: Vigot Et al.
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
Authors: Shin Et al.
J Cereb Blood Flow Metab 2006;26:1018
Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Authors: Casado Et al.
Proc Natl Acad Sci U S A 2000;97:11593
Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
Authors: Tacconi Et al.
Br J Pharmacol 1993;108:577
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