7-Chlorokynurenic acid

  ( 6 citations )    
Product Datasheet
Catalog Number:0237
Chemical Name:7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Available as part of the NMDA Receptor - Glycine Site Tocriset™. Sodium Salt also available.

Technical Data
  • M.Wt:
    223.62
  • Formula:
    C10H6ClNO3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    18000-24-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid include:

6 Citations: Showing 1 - 6
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  1. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
    Authors: Biase Et al.
    Proc Natl Acad Sci U S A  2011;31:12650
  2. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
    Authors: Baltan Et al.
    J Neurosci  2008;28:1479
  3. Differential compartmentalization and distinct functions of GABAB receptor variants.
    Authors: Vigot Et al.
    Neuron  2006;50:589
  4. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
    Authors: Shin Et al.
    J Cereb Blood Flow Metab  2006;26:1018
  5. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Proc Natl Acad Sci U S A  2000;97:11593
  6. Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
    Authors: Tacconi Et al.
    Br J Pharmacol  1993;108:577

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7-Chlorokynurenic acid sodium salt

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