7-Chlorokynurenic acid

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0237/10
0237/50
7-Chlorokynurenic acid | CAS No. 18000-24-3 | Glutamate (EAAT) Transporter Inhibitors
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Description: Potent competitive inhibitor of L-glutamate uptake

Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid

Purity: ≥98%

Product Details
Citations (6)
Supplemental Products
Reviews

Biological Activity

7-Chlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Sodium Salt also available.

Technical Data

M.Wt:
223.62
Formula:
C10H6ClNO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
18000-24-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
    Kretschmer et al.
    Eur.J.Pharmacol., 1995;280:37
  3. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
    Bartlett et al.
    Neuropharmacology, 1998;37:839
  4. 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
    Kemp et al.
    Proc.Natl.Acad.Sci.U.S.A., 1988;85:6547
  5. Characterization of [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain.
    Donald et al.
    Br.J.Pharmacol., 1988;95:892P

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Citations for 7-Chlorokynurenic acid

The citations listed below are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid include:

6 Citations: Showing 1 - 6

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