A 425619

Catalog # Availability Size / Price Qty
5781/10
5781/50
A 425619 | CAS No. 581809-67-8 | TRPV Antagonists
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Description: Potent TRPV1 antagonist

Chemical Name: N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Potent TRPV1 antagonist (IC50 = 3-9 nM). Blocks capsaicin-evoked currents in rat DRG neurons and inhibits TRPV1-activation by anandamide (Cat. No. 1339) and N-arachidonoyl-dopamine. Reduces pain in inflammatory, postoperative and osteoarthritic in vivo pain models.

Technical Data

M.Wt:
345.32
Formula:
C18H14F3N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
581809-67-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for A 425619

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Inhibiting calcium entry in human mast cells stimulated with cortistatin
By ANANTH KUMAR KAMMALA on 01/30/2021
Application: Species: Human

A425619 product was used to study the role of MrgprX2 receptor in calcium mobilization in human mast cells. At a concentration of 0.01 and 0.03uM A425619 inhibited calcium entry significantly when stimulated mast cells with cortistatin.

PMID: 32038646 Reference

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